💊
Typical Dose 75-125 mg
⏱️
Duration 3h - 5h
⚠️
Interaction Risk Moderate
🔗
Combinations 26
🔬
Detection Methods 4
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Description

The world's most popular empathogen with powerful pro-social effects. Has been strongly linked to cognitive decline in excess. Popular at parties, it is often sold in powder or in pills, and may be adulterated with other similar chemicals.

Effects & Dosing

Dosage

Oral

Light Common Strong
40-75 mg 75-125 mg 125-175 mg

Duration

Oral

Onset 20 min - 1h 10m
Total Duration 3h - 5h
After Effects 1h - 72h
Safety & Risks

Safer Use

  1. NOTE: Higher doses increase neurotoxic effects

Detection Times

Method Detection Window
Blood 12–24 hours
Saliva 1–3 days
Urine 2–4 days
Hair 1–90 days

Note: Can trigger positive on amphetamine immunoassays. Also detectable on specific MDMA/MDA panel.

Interactions

26 known interactions with other substances.

Dangerous 5
aMTDXMPCPTramadolMAOIs

This combination can easily lead to hypermanic states

Tramadol and stimulants both increase the risk of seizures.

MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAO-A inhibitors with MDMA will lead to hypertensive crises.

⚠️ Caution 9
DOxNBOMes2C-T-x5-MeO-xxTMXECocaineCaffeineAlcoholGHB

The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.

Some of the 5-MeO tryptamines are a bit unpredictable and should be mixed with MDMA with care

There have been reports of risky serotonergic interactions when the two are taken at the same time, but MXE taken to the end of an MDMA experience does not appear to cause the same issues.

Cocaine blocks some of the desirable effects of MDMA while increasing the risk of heart attack.

Caffiene is not really necessary with MDMA and increases any neurotoxic effects from MDMA

Both MDMA and alcohol cause dehydration. Approach this combination with caution, moderation and sufficient hydration. More than a small amount of alcohol will dull the euphoria of MDMA

Large amounts of GHB may overwhelm the effects of MDMA on the comedown.

Low Risk 12
Synergy
Decrease
BenzodiazepinesSSRIs
No Synergy
Opioids

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