Description
A popular dissociative drug which is an analogue of ketamine, though less sedating and more potent by weight, with a subjectively more 'complicated' set of effects.
Dosage
Oral
| Light | Common | Strong |
|---|---|---|
| 15-25 mg | 25-35 | 40-65 mg |
Duration
Oral
Safer Use
- NOTE: Bodyweight plays a slight factor in MXE dosing, these are values for a 175lb (80kg) male
- Alcohol, Benzodiazepines, Opioids, Other CNS depressants, including substances that have an effect on Serotonin (For example, yet not limited to MDMA, Amphetamine, and other stimulants)
Detection Times
| Method | Detection Window |
|---|---|
| Urine | 2–5 days |
Note: Methoxetamine. Not part of standard drug panels. May cross-react with PCP immunoassays. Requires specific testing for confirmation.
Interactions
26 known interactions with other substances.
There is a high risk of memory loss, vomiting and severe ataxia from this combination.
Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
This combination can potentiate the effects of the opioid
MAO-B inhibitors appear to increase the potency of MXE. MAO-A inhbitors have some negative reports associated with the combination but there isn't much information available
As an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense
As an NMDA antagonist MXE potentiates NBOMes which can be unpleasantly intense
There are no reports available about this combination
Risk of tachycardia, hypertension, and manic states
There have been reports of risky serotonergic interactions when the two are taken at the same time, but MXE taken to the end of an MDMA experience does not appear to cause the same issues.
Stimulants taken with MXE can lead to hypermanic states much more easily, especially if sleep is avoided.
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess.
Depending on the SSRI this combination can be unpredictable
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