💊
Typical Dose 25-50 mg
⏱
Duration 45 min - 1h
⚠
Interaction Risk Low
🔗
Combinations 26
🔬
Detection Methods 1
Start Trip

Description

A popular and powerful psychedelic, typically used in two ways; either it is vapourised for a short 'breakthrough' experience, or it is taken in combination with an enzyme inhibitor for a long, intense trip (this is also known as ayahuasca or pharmahuasca).

Effects & Dosing

Dosage

Insufflated

Light Common Strong
10-25 mg 25-50 mg 50-125 mg+

Intravenous

Light Common Strong
10-15 mg 15-25 mg 25-40 mg

Smoked

Threshold Light Common Strong Heavy
5-10 mg 10-15 mg 15-25 mg 25-35 mg 35-35 mg+

Duration

Insufflated

Onset 3 min - 5 min
Total Duration 45 min - 1h

Oral (with MAOI)

Total Duration 3h - 7h

Smoked

Onset 0 min - 2 min
Total Duration 3 min - 10 min

Oral

Onset 20 min - 45 min
After Effects 15 min - 1h
Safety & Risks

Safer Use

  1. NOTE: These figures are for 100% effective vaporization methods. Most methods are not 100% effective. Likelyhood of having a "breakthrough" experience increases with dose.

Detection Times

Method Detection Window
Urine 12–24 hours

Note: Not part of standard drug panels. Extremely rapid metabolism. Requires highly specialized testing.

Interactions

26 known interactions with other substances.

⛔ Dangerous 1

Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

⚠ Caution 3
CannabisAmphetaminesCocaine

Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.

Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences

✅ Low Risk 22
Synergy
LSDMushroomsMescalineDOxNBOMes2C-x2C-T-xaMT5-MeO-xxTKetamineMXEDXMPCPNitrousMDMAMAOIs
Decrease
AlcoholGHBBenzodiazepinesSSRIs
No Synergy
CaffeineOpioids

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